magnetic-optical biosensing
עמוס דניאלי
Identity: verifiedThe Bar-Ilan CRIS profile and linked academic CV identify Amos Danielli and align his biomarker-detection work with the inspected patent record. [45][46]
Documented foundation
Bar-Ilan engineering researcher developing magnetic and optical methods for rapid, sensitive biomarker detection and portable diagnostic workflows.[45][46]
fluorescence immunoassaysmagnetic-particle concentrationoptical background suppressionportable diagnostic instrumentation
The linked academic CV was inspected; it is dated December 2023 and therefore does not cover the full current period.[46]
Open CVRepresentative records, not a complete publication list. Metadata confirms attribution; it does not independently replicate a result.
2026 · paper
The paper introduces temporal separation of background and bead-bound fluorescence in a magnetic-bead immunoassay and reports a bounded serum-sample feasibility assessment.[47]
4 catalogued patent records · 3 identified families · family unassigned for 1 record
Coverage: Partial inventor search
Three additional representative families across MagBiosense and Bar-Ilan. The inspected CV lists the Ramot/Tel-Aviv baseline-family continuations US9575068B2, US10175246B2 and US11275083B2; the last record's Family table explicitly links baseline US8465989B2, so variants are intentionally omitted as additional inventions. Self-reported 62/726468 and CV-only EP/HK records retained as follow-up leads, not asserted public grants. CV dates are not substituted for publication dates; no all-affiliation worldwide coverage claim.
US20240219302A1 · Published 2024-07-04
Published patent document inspected
Publication assignee: Bar Ilan University
Amos Danielli and the named co-inventors/subject match his first-party CV patent list; the public patent record independently supplies identifier, publication date and listed assignee.[185][212]
US20230257832A1 · Published 2023-08-17
Published patent document inspected
Publication assignee: Bar Ilan University
Amos Danielli and the named co-inventors/subject match his first-party CV patent list; the public patent record independently supplies identifier, publication date and listed assignee.[183][212]
WO2018185672A1 · Published 2018-10-11
Published patent document inspected
Publication assignee: Magbiosense Inc
Amos Danielli and the named co-inventors/subject match his first-party CV patent list; the public patent record independently supplies identifier, publication date and listed assignee.[209][212]
US8465989B2
Original report record
Preserved from the original report; see its cited evidence and limitations.[48]
Original evidence: verified record
One attributable US grant was inspected and is also listed in the CV; current legal ownership and complete family scope were not assessed.[46][48]
Records are counted separately from identified families. Author-reported entries are labelled and may still need publication verification. Inventorship, publication-time applicant and current ownership are different facts. No legal-status, patentability or freedom-to-operate conclusion is made.
Scores prioritize research fit from 1–10; they are not probabilities.
Review: Reviewed with limitations
Proposed capability matches, not confirmed relationships. Scores are analyst judgments with low forecast confidence; researcher interests, capacity and feasibility need confirmation.
10 candidates
Connection 1
Original proposal
Proposal hypothesis: Danielli's magnetic-optical assays and Popovtzer's nanoparticle functionalization meet on specific binding versus sample-background interference.[45][46][47][53][54]
Proposed first test: Compare a reference bead assay with one candidate functionalization in a blinded dilution and interference panel; measure recovery and nonspecific signal.
Rank 1/10; fit 9/10 (4 topic overlap + 3 complementarity + 2 feasible first test). Preserved original co-membership proposal in o06. No strictly higher-scoring candidate displaces this original. No compatibility between gold probes and the selected magnetic assay is assumed before bench qualification. No automatic score boost for original membership. Equal scores use existing-first, then stable researcher ID.
Analyst proposal hypothesis, not an established collaboration, commitment, evidence-confidence rating or assessment of researcher quality; confirm participation and access before work.
Connection 2
Original proposal
Proposal hypothesis: Danielli can identify a background-limited assay and Lewi can model a metasurface filter or collection element for that measured optical bottleneck.[45][46][47][67][68]
Proposed first test: Use the reference assay spectrum in an optical model; compare signal collection and background rejection with a conventional filter.
Rank 2/10; fit 8/10 (3 topic overlap + 3 complementarity + 2 feasible first test). Preserved original co-membership proposal in o06. Higher-scoring Rachela Popovtzer (9/10) precedes this original; its own rank reflects the following limitation: The original photonic addition is conditional on a demonstrated optical bottleneck and plausible fabrication tolerances. No automatic score boost for original membership. Equal scores use existing-first, then stable researcher ID.
Analyst proposal hypothesis, not an established collaboration, commitment, evidence-confidence rating or assessment of researcher quality; confirm participation and access before work. Original initiative conditions remain: o06 Tomer Lewi: Conditional later role: add a photonic component only if the baseline study identifies an optical bottleneck that it can address.
Connection 3
Original proposal
Proposal hypothesis: Danielli's optical background suppression and Zalevsky's biomedical optics could separate sample preparation gains from readout gains.[45][46][47][116][117][138]
Proposed first test: Measure a fixed phantom/dilution panel with a standard readout and a proposed optical reconstruction; report detection repeatability and background sensitivity.
Rank 3/10; fit 8/10 (3 topic overlap + 3 complementarity + 2 feasible first test). Preserved original co-membership proposal in o06. Higher-scoring Rachela Popovtzer (9/10) precedes this original; its own rank reflects the following limitation: A new readout must target the dominant measured error; broader imaging expertise alone is not evidence of assay improvement. No automatic score boost for original membership. Equal scores use existing-first, then stable researcher ID.
Analyst proposal hypothesis, not an established collaboration, commitment, evidence-confidence rating or assessment of researcher quality; confirm participation and access before work. Original initiative conditions remain: o06 Zeev Zalevsky: Conditional later role: assess an imaging/readout change only if it targets the dominant measured bottleneck.
Connection 4
Proposal hypothesis: Tesler's fouling-resistant coatings could address nonspecific adsorption in Danielli's magnetic-optical biomarker assays.[12][13][45][46][47]
Proposed first test: Compare coated and uncoated assay-contact surfaces in a blank/spiked dilution panel on recovery and carryover.
Rank 4/10; fit 8/10 (3 topic overlap + 3 complementarity + 2 feasible first test). New pairing outside the frozen portfolio co-member graph. The coating must not remove analyte or disrupt magnetic bead handling. Equal scores use existing-first, then stable researcher ID.
Analyst proposal hypothesis, not an established collaboration, commitment, evidence-confidence rating or assessment of researcher quality; confirm participation and access before work.
Connection 5
Proposal hypothesis: Fridman's time-domain optics and Danielli's temporally modulated background subtraction meet on separating weak signals from structured backgrounds.[34][45][46][47]
Proposed first test: Replay synthetic fluorescence traces through two modulation/temporal-filter schemes; compare signal recovery at equal acquisition time.
Rank 5/10; fit 8/10 (3 topic overlap + 3 complementarity + 2 feasible first test). New pairing outside the frozen portfolio co-member graph. Any improvement must survive detector bandwidth and sample-background constraints. Equal scores use existing-first, then stable researcher ID.
Analyst proposal hypothesis, not an established collaboration, commitment, evidence-confidence rating or assessment of researcher quality; confirm participation and access before work.
Connection 6
Proposal hypothesis: Ozana's single-photon optical instrumentation and Danielli's background-suppression assays meet on detection under low count rates.[41][42][45][46][47]
Proposed first test: Simulate a weak fluorescence time series with known background and compare photon-counting and analog readout on recovery and false positives.
Rank 6/10; fit 8/10 (3 topic overlap + 3 complementarity + 2 feasible first test). New pairing outside the frozen portfolio co-member graph. Detector choice must match assay timescales and fluorescence background. Equal scores use existing-first, then stable researcher ID.
Analyst proposal hypothesis, not an established collaboration, commitment, evidence-confidence rating or assessment of researcher quality; confirm participation and access before work.
Connection 7
Proposal hypothesis: Danielli's portable optical assay requirements complement Fish's low-power sensor and biomedical circuit design.[45][46][47][89][90]
Proposed first test: Model two optical readout circuits under the same assay signal/noise envelope; compare energy per measurement and detection error.
Rank 7/10; fit 8/10 (3 topic overlap + 3 complementarity + 2 feasible first test). New pairing outside the frozen portfolio co-member graph. No fabricated circuit or validated assay-chip integration is assumed. Equal scores use existing-first, then stable researcher ID.
Analyst proposal hypothesis, not an established collaboration, commitment, evidence-confidence rating or assessment of researcher quality; confirm participation and access before work.
Connection 8
Proposal hypothesis: Shefi's magnetic cell manipulation and Danielli's magnetic-optical detection could separate handling effects from a soluble biomarker readout.[8][45][46][47]
Proposed first test: Specify a culture-supernatant assay with magnetic-handling and no-handling controls; measure spike recovery and background.
Rank 8/10; fit 7/10 (2 topic overlap + 3 complementarity + 2 feasible first test). New pairing outside the frozen portfolio co-member graph. Shared use of magnetism does not guarantee compatible particles, forces or biological conditions. Equal scores use existing-first, then stable researcher ID.
Analyst proposal hypothesis, not an established collaboration, commitment, evidence-confidence rating or assessment of researcher quality; confirm participation and access before work.
Connection 9
Proposal hypothesis: Blau's spectral-mode control could test multiplexed readout in Danielli's optical biomarker assays.[37][38][45][46][47]
Proposed first test: Model two fluorescence bands through a mode-selective optical response and compare cross-talk with standard bandpass filters.
Rank 9/10; fit 7/10 (2 topic overlap + 3 complementarity + 2 feasible first test). New pairing outside the frozen portfolio co-member graph. Fluorescence is not assumed to retain quantum coherence; the proposal is classical spectral discrimination. Equal scores use existing-first, then stable researcher ID.
Analyst proposal hypothesis, not an established collaboration, commitment, evidence-confidence rating or assessment of researcher quality; confirm participation and access before work.
Connection 10
Proposal hypothesis: Kalisky can define a cell-state marker question while Danielli tests whether a portable protein assay reflects the corresponding molecular state.[45][46][47][70]
Proposed first test: On a public matched transcript/protein dataset or a prespecified future panel, compare marker association with a cell-composition baseline.
Rank 10/10; fit 7/10 (2 topic overlap + 3 complementarity + 2 feasible first test). New pairing outside the frozen portfolio co-member graph. Transcript abundance is not protein concentration; matched data must exist before assay claims. Equal scores use existing-first, then stable researcher ID.
Analyst proposal hypothesis, not an established collaboration, commitment, evidence-confidence rating or assessment of researcher quality; confirm participation and access before work.
10 candidates
Connection 1
Harvard University and the Wyss Institute
Original proposal
Walt's official profile documents single-molecule diagnostics and biomarker assays, complementing Danielli's magnetic-optical concentration and background suppression; this is a proposed match only.[45][46][49][501]
Run a blinded dilution panel for two biomarkers and compare count linearity, cross-reactivity and detection limits against a reference assay.
Rank 1/10 after semantic revision; analyst score 9 = max(1, 4+3+2): topic overlap 4/4, complementarity 3/3, feasible first test 2/3. The experiment, numerical inputs or identity/scope needs confirmation before execution. Original remains first under these components; original status breaks equal-score ties only, without a prestige bonus.
Proposed fit, not an assertion of a new or active relationship. Independent review pending; forecast confidence low. Partner interest, capacity, data access and any required experimental approvals/resources are unverified.
Connection 2
University of California, Berkeley
Proposed capability match: Amos Danielli's fluorescence immunoassays, magnetic-particle concentration can be paired with Jun-Chau Chien's documented biosensors, microfluidics for digital single-molecule magnetic-optical diagnostics. The specific contribution is microfluidic and mixed-signal measurement; this transfer is an analyst hypothesis.[45][46][436]
Design a two-channel acquisition or microfluidic calibration experiment with a matched blank using a planned magnetic-particle fluorescence assay with a fixed analyte dilution series. Compare measurement noise, cross-channel contamination and readout energy with the same assay without the proposed concentration/readout module.
Rank 2/10 after semantic revision; analyst score 9 = max(1, 4+3+2): topic overlap 4/4, complementarity 3/3, feasible first test 2/3. The experiment, numerical inputs or identity/scope needs confirmation before execution.
Proposed fit, not an assertion of a new or active relationship. Independent review pending; forecast confidence low. Partner interest, capacity, data access and any required experimental approvals/resources are unverified.
Connection 3
University of California, Los Angeles
Proposed capability match for Amos Danielli with Aydogan Ozcan: Computational imaging could improve assay image analysis once bead images and a counting/concentration target are defined; the control must change only the analysis method.[45][46][118][482]
Render fluorescence assay images with known bead positions, fluorophore counts, blur and background across a simulated dilution series. Hold the concentration/readout hardware model fixed; compare spot-counting and computational reconstruction by bead-count error and concentration-estimation error on identical images. Vary illumination and overlap as held-out conditions.
Rank 3/10 after semantic revision; analyst score 8 = max(1, 3+3+2): topic overlap 3/4, complementarity 3/3, feasible first test 2/3. Computational imaging could improve assay image analysis once bead images and a counting/concentration target are defined; the control must change only the analysis method. The experiment, numerical inputs or identity/scope needs confirmation before execution.
Proposed fit, not an assertion of a new or active relationship. Independent review pending; forecast confidence low. Partner interest, capacity, data access and any required experimental approvals/resources are unverified. Post-review scope: Computational imaging could improve assay image analysis once bead images and a counting/concentration target are defined; the control must change only the analysis method. This revised proposal awaits independent targeted re-review; simulated outcomes would establish model behavior only, not biological, clinical or deployed benefit.
Connection 4
Stanford University
Proposed capability match: Amos Danielli's fluorescence immunoassays, magnetic-particle concentration can be paired with Stephen Quake's documented microfluidic single-cell analysis, DNA sequencing for digital single-molecule magnetic-optical diagnostics. The specific contribution is microfluidic isolation and biological measurement; this transfer is an analyst hypothesis.[45][46][487]
Design a controlled dilution or isolation experiment with matched input counts and blank channels using a planned magnetic-particle fluorescence assay with a fixed analyte dilution series. Compare capture efficiency, contamination and measurement variance with the same assay without the proposed concentration/readout module.
Rank 4/10 after semantic revision; analyst score 8 = max(1, 3+3+2): topic overlap 3/4, complementarity 3/3, feasible first test 2/3. The experiment, numerical inputs or identity/scope needs confirmation before execution.
Proposed fit, not an assertion of a new or active relationship. Independent review pending; forecast confidence low. Partner interest, capacity, data access and any required experimental approvals/resources are unverified.
Connection 5
The Pennsylvania State University
Proposed capability match: Amos Danielli's fluorescence immunoassays, magnetic-particle concentration can be paired with Tak-Sing Wong's documented liquid-infused slippery surfaces, interfacial phenomena for digital single-molecule magnetic-optical diagnostics. The specific contribution is assay surface enrichment; this transfer is an analyst hypothesis.[45][46][502]
Compare sample concentration on slippery and conventional assay surfaces before optical readout using a planned magnetic-particle fluorescence assay with a fixed analyte dilution series. Compare recovery, nonspecific adsorption and between-run variation with the same assay without the proposed concentration/readout module.
Rank 5/10 after semantic revision; analyst score 8 = max(1, 3+3+2): topic overlap 3/4, complementarity 3/3, feasible first test 2/3. The experiment, numerical inputs or identity/scope needs confirmation before execution.
Proposed fit, not an assertion of a new or active relationship. Independent review pending; forecast confidence low. Partner interest, capacity, data access and any required experimental approvals/resources are unverified. Contribution is restricted to the scope stated in the first test.
Connection 6
Massachusetts Institute of Technology
Proposed capability match: Amos Danielli's fluorescence immunoassays, magnetic-particle concentration can be paired with Paula Hammond's documented layer-by-layer nanoparticles, staged drug delivery for digital single-molecule magnetic-optical diagnostics. The specific contribution is assay particle surface chemistry; this transfer is an analyst hypothesis.[45][46][56][460]
Compare two polymer-layer orders on a particle surrogate at equal binding-site density using a planned magnetic-particle fluorescence assay with a fixed analyte dilution series. Compare specific-to-nonspecific binding ratio and wash retention with the same assay without the proposed concentration/readout module.
Rank 6/10 after semantic revision; analyst score 7 = max(1, 2+3+2): topic overlap 2/4, complementarity 3/3, feasible first test 2/3. The experiment, numerical inputs or identity/scope needs confirmation before execution.
Proposed fit, not an assertion of a new or active relationship. Independent review pending; forecast confidence low. Partner interest, capacity, data access and any required experimental approvals/resources are unverified. Contribution is restricted to the scope stated in the first test. The official page has differing leadership titles in its header and biography; only MIT affiliation is asserted.
Connection 7
Harvard University
Proposed capability match: Amos Danielli's fluorescence immunoassays, magnetic-particle concentration can be paired with Samir Mitragotri's documented drug delivery, biological barriers for digital single-molecule magnetic-optical diagnostics. The specific contribution is carrier-analyte access and interference controls; this transfer is an analyst hypothesis.[45][46][477]
Compare bead/analyte interaction in two protein-background conditions using a planned magnetic-particle fluorescence assay with a fixed analyte dilution series. Compare recovery and matrix interference with the same assay without the proposed concentration/readout module.
Rank 7/10 after semantic revision; analyst score 7 = max(1, 2+3+2): topic overlap 2/4, complementarity 3/3, feasible first test 2/3. The experiment, numerical inputs or identity/scope needs confirmation before execution.
Proposed fit, not an assertion of a new or active relationship. Independent review pending; forecast confidence low. Partner interest, capacity, data access and any required experimental approvals/resources are unverified. Contribution is restricted to the scope stated in the first test.
Connection 8
University of California, Berkeley
Proposed capability match: Amos Danielli's fluorescence immunoassays, magnetic-particle concentration can be paired with Rikky Muller's documented integrated circuits, biosystems for digital single-molecule magnetic-optical diagnostics. The specific contribution is bioelectronic acquisition interfaces; this transfer is an analyst hypothesis.[45][46][436]
Simulate front-end noise and sampling duty cycle before selecting a sensor interface using a planned magnetic-particle fluorescence assay with a fixed analyte dilution series. Compare signal-to-noise ratio and acquisition power with the same assay without the proposed concentration/readout module.
Rank 8/10 after semantic revision; analyst score 7 = max(1, 2+3+2): topic overlap 2/4, complementarity 3/3, feasible first test 2/3. The experiment, numerical inputs or identity/scope needs confirmation before execution.
Proposed fit, not an assertion of a new or active relationship. Independent review pending; forecast confidence low. Partner interest, capacity, data access and any required experimental approvals/resources are unverified.
Connection 9
University of California, Berkeley
Proposed capability match: Amos Danielli's fluorescence immunoassays, magnetic-particle concentration can be paired with Jan M. Rabaey's documented low-power integrated circuits, wireless sensor systems for digital single-molecule magnetic-optical diagnostics. The specific contribution is acquisition, computation and radio power budgeting; this transfer is an analyst hypothesis.[4][45][46][488]
Replay two duty-cycle policies across the acquisition, compute and radio stages using a planned magnetic-particle fluorescence assay with a fixed analyte dilution series. Compare energy per valid result and recovery latency with the same assay without the proposed concentration/readout module.
Rank 9/10 after semantic revision; analyst score 7 = max(1, 2+3+2): topic overlap 2/4, complementarity 3/3, feasible first test 2/3. The experiment, numerical inputs or identity/scope needs confirmation before execution.
Proposed fit, not an assertion of a new or active relationship. Independent review pending; forecast confidence low. Partner interest, capacity, data access and any required experimental approvals/resources are unverified.
Connection 10
Harvard University
Proposed capability match for Amos Danielli with Donald E. Ingber: An organ-chip branch can test whether assay recovery confounds a barrier measurement, but a fluorescence dilution series alone establishes no permeability or toxicity endpoint.[45][46][462]
Specify a separate barrier-chip transport model with a donor compartment, receiver compartment, stipulated permeability and magnetic fluorescent tracer recovery. Compare concentration-estimation bias with and without a concentration module at identical tracer dose and true permeability. Include an acellular transport control; infer neither toxicity nor biological-barrier efficacy from this model.
Rank 10/10 after semantic revision; analyst score 6 = max(1, 2+2+2): topic overlap 2/4, complementarity 2/3, feasible first test 2/3. An organ-chip branch can test whether assay recovery confounds a barrier measurement, but a fluorescence dilution series alone establishes no permeability or toxicity endpoint. The experiment, numerical inputs or identity/scope needs confirmation before execution.
Proposed fit, not an assertion of a new or active relationship. Independent review pending; forecast confidence low. Partner interest, capacity, data access and any required experimental approvals/resources are unverified. Post-review scope: An organ-chip branch can test whether assay recovery confounds a barrier measurement, but a fluorescence dilution series alone establishes no permeability or toxicity endpoint. This revised proposal awaits independent targeted re-review; simulated outcomes would establish model behavior only, not biological, clinical or deployed benefit.
Amos Danielli's documented expertise includes magnetic-particle concentration, optical background suppression and rapid biomarker assays. [45][46][47][48]
High confidenceReview: reviewedThe available CV ends in 2023 and portfolio review was selective.
Hypothesis: Danielli could combine magnetic-optical enrichment with single-molecule counting for portable multiplexed diagnostics. [47][49]
Low confidenceReview: reviewedAssay statistics, multiplex interference, manufacturing and clinical performance are unverified.
